Molecular Formula: C7H3Cl3O
Molecular Weight: 209.46
|
Melting point |
28 °C (lit.) |
|
Boiling point |
135-137 °C/25 mmHg (lit.) |
|
Density |
135 |
|
vapor pressure |
0.1 mm Hg ( 32 °C) |
|
refractive index |
n20/D 1.582(lit.) |
|
Flash point |
>230 °F |
|
storage temp. |
Refrigerator (+4°C) |
|
solubility |
soluble in Benzene,Toluene |
|
form |
powder to lump to clear liquid |
|
color |
White or Colorless to Almost white or Almost colorless |
|
Sensitive |
Moisture Sensitive |
|
Symbol(GHS) |
|
|
Signal word |
Danger |
|
Hazard Codes |
C |
|
Hazard Note |
Corrosive |
|
HazardClass |
8 |
|
PackingGroup |
II |
|
HS Code |
29163900 |
3,5-Dichlorobenzoyl chloride is an important intermediate of pesticide, medicine and dye. In pesticide production, pesticides can be prepared by benzoic acid reaction; In the field of medicine, headache drugs and antidiuretic hormone drugs can be prepared. It is an important intermediate for the synthesis of pesticide herbicides pentoxachlor and is widely used in the fields of pesticides, medicine, photosensitive materials and so on.
3,5-Dichlorobenzoyl chloride is a useful intermediate for organic synthesis and other pharmaceutical processes. 3,5-Dichlorobenzoyl chloride has been used in the preparation of:
N-(1,1-dimethylpropynyl)-3,5-dichlorobenzamide, herbicide
(3,5-dichlorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone
3,5-Dichlorobenzoyl chloride is an important intermediate for the synthesis of fenpropargyl, which is widely used in pesticide, medicine, photosensitive materials and other fields.
3,5-Dichlorobenzoyl chloride is obtained by reacting by aryl carboxylic acid with DMF. Dissolve aryl carboxylic acid (10.0 mmol) in 50 mL DCM with drops of DMF to a 100 mL roundbottomed flask. Cool the mixture to 0°C. Add oxalyl chloride (20.0 mmol, 2.0 equivalents) dropwise to the reaction mixture. Allow the reaction mixture to react for another 4 hours. Concentrate the solvent in vacuo. Use the remaining residue directly.
