(hexafluoro propanol)
Hexafluoro propanol (HFP), particularly 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), is a fluorinated alcohol renowned for its unique chemical properties. With a boiling point of 58°C and a flash point below 0°C, HFIP serves as a high-performance solvent in pharmaceuticals, electronics, and advanced material synthesis. Its low nucleophilicity and high polarity enable exceptional solubility for polymers like polyamides and polyesters, making it indispensable in R&D and industrial applications.
HFIP outperforms traditional solvents such as acetone or ethanol in multiple dimensions. Key advantages include:
Manufacturer | Purity (%) | Primary Applications | Price (USD/kg) | Thermal Stability (°C) |
---|---|---|---|---|
ChemCorp Ltd. | 99.8 | Pharma, Polymers | 220 | 210 |
FluoroTech Inc. | 99.5 | Electronics, Coatings | 195 | 195 |
PureSolutions AG | 99.9 | Research, Specialty Chemicals | 245 | 220 |
Tailored HFIP formulations address sector-specific challenges. For instance:
While HFIP exhibits low acute toxicity (LD50 >2,000 mg/kg), prolonged exposure requires PPE compliance. Storage in nickel-alloy containers prevents degradation, and waste treatment via incineration at 1,100°C ensures complete fluorocarbon breakdown.
With the global fluorinated solvents market projected to grow at 6.8% CAGR through 2030, HFIP remains at the forefront of material science. Emerging applications in battery electrolytes and carbon capture systems underscore its adaptability, while manufacturers’ investments in closed-loop production (90% solvent recovery rate) align with circular economy goals.
(hexafluoro propanol)
A: 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) has the formula CF₃CF₂CH₂OH. It features six fluorine atoms attached to two trifluoromethyl groups and a hydroxyl group on the central carbon. This structure gives it strong polarity and acidity.
A: HFIP is widely used as a solvent for polymers, peptides, and resins due to its high polarity. It also serves as a reagent in organic synthesis and pharmaceutical production. Additionally, it aids in protein structure analysis and chromatography.
A: Use gloves, goggles, and ventilation to avoid skin/eye contact and inhalation. Store in a cool, dry place away from incompatible materials like strong bases. Follow SDS guidelines for spills or exposure emergencies.
A: The abbreviation HFIP stands for HexaFluoro IsoPropanol, reflecting its six fluorine atoms and isopropanol-derived structure. This shorthand simplifies referencing in technical literature. The "2-propanol" denotes hydroxyl group positioning.
A: Its strong hydrogen-bond-donating ability and low nucleophilicity enable dissolution of stubborn polymers and biomolecules. HFIP also exhibits high density (1.6 g/mL) and miscibility with many organic solvents. These properties drive its use in specialized industrial and research settings.