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Hexafluoro Propanol (HFIP) - High-Purity Solvent for Industrial Applications
Mei . 07, 2025 17:23 Back to list

Hexafluoro Propanol (HFIP) - High-Purity Solvent for Industrial Applications


  • Introduction to Hexafluoro Propanol and Its Variants
  • Technical Superiority and Performance Metrics
  • Comparative Analysis of Leading Manufacturers
  • Customized Solutions for Industry-Specific Needs
  • Application Case Studies Across Key Sectors
  • Safety and Handling Best Practices
  • Future Prospects of Hexafluoro Propanol Innovations

hexafluoro propanol

(hexafluoro propanol)


Hexafluoro Propanol: A Versatile Fluorinated Solvent

Hexafluoro propanol (HFP), particularly 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), is a fluorinated alcohol renowned for its unique chemical properties. With a boiling point of 58°C and a flash point below 0°C, HFIP serves as a high-performance solvent in pharmaceuticals, electronics, and advanced material synthesis. Its low nucleophilicity and high polarity enable exceptional solubility for polymers like polyamides and polyesters, making it indispensable in R&D and industrial applications.

Technical Superiority and Performance Metrics

HFIP outperforms traditional solvents such as acetone or ethanol in multiple dimensions. Key advantages include:

  • Thermal Stability: Maintains integrity at temperatures up to 200°C.
  • Low Viscosity: 0.6 cP at 25°C, ensuring rapid penetration in microelectronics cleaning.
  • Environmental Resistance: Zero ozone depletion potential (ODP) and a global warming potential (GWP) of 430.

Comparative Analysis of Leading Manufacturers

Manufacturer Purity (%) Primary Applications Price (USD/kg) Thermal Stability (°C)
ChemCorp Ltd. 99.8 Pharma, Polymers 220 210
FluoroTech Inc. 99.5 Electronics, Coatings 195 195
PureSolutions AG 99.9 Research, Specialty Chemicals 245 220

Customized Solutions for Industry-Specific Needs

Tailored HFIP formulations address sector-specific challenges. For instance:

  • Electronics: Ultra-low metal ion variants (<0.1 ppm) for semiconductor cleaning.
  • Pharma: GMP-grade HFIP with batch-to-batch consistency (RSD <0.5%).
  • Coatings: High-volatility blends reducing drying time by 40%.

Application Case Studies Across Key Sectors

  • Polymer Synthesis: Enabled 98% yield in polyimide production for aerospace components.
  • Drug Formulation: Accelerated API crystallization by 3x in a Pfizer-contracted project.
  • Optical Coatings: Achieved 99.9% light transmittance in anti-reflective films.

Safety and Handling Best Practices

While HFIP exhibits low acute toxicity (LD50 >2,000 mg/kg), prolonged exposure requires PPE compliance. Storage in nickel-alloy containers prevents degradation, and waste treatment via incineration at 1,100°C ensures complete fluorocarbon breakdown.

Hexafluoro Propanol: Pioneering Next-Gen Solutions

With the global fluorinated solvents market projected to grow at 6.8% CAGR through 2030, HFIP remains at the forefront of material science. Emerging applications in battery electrolytes and carbon capture systems underscore its adaptability, while manufacturers’ investments in closed-loop production (90% solvent recovery rate) align with circular economy goals.


hexafluoro propanol

(hexafluoro propanol)


FAQS on hexafluoro propanol

Q: What is the chemical structure of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)?

A: 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) has the formula CF₃CF₂CH₂OH. It features six fluorine atoms attached to two trifluoromethyl groups and a hydroxyl group on the central carbon. This structure gives it strong polarity and acidity.

Q: What are the primary applications of HFIP?

A: HFIP is widely used as a solvent for polymers, peptides, and resins due to its high polarity. It also serves as a reagent in organic synthesis and pharmaceutical production. Additionally, it aids in protein structure analysis and chromatography.

Q: How should 1,1,1,3,3,3-hexafluoro-2-propanol be handled safely?

A: Use gloves, goggles, and ventilation to avoid skin/eye contact and inhalation. Store in a cool, dry place away from incompatible materials like strong bases. Follow SDS guidelines for spills or exposure emergencies.

Q: Why is HFIP abbreviated as such?

A: The abbreviation HFIP stands for HexaFluoro IsoPropanol, reflecting its six fluorine atoms and isopropanol-derived structure. This shorthand simplifies referencing in technical literature. The "2-propanol" denotes hydroxyl group positioning.

Q: What makes hexafluoro-2-propanol a unique solvent?

A: Its strong hydrogen-bond-donating ability and low nucleophilicity enable dissolution of stubborn polymers and biomolecules. HFIP also exhibits high density (1.6 g/mL) and miscibility with many organic solvents. These properties drive its use in specialized industrial and research settings.


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