(organic solvent dmso)
Dimethyl sulfoxide (DMSO) is a polar aprotic organic solvent renowned for its exceptional solubility properties. With a boiling point of 189°C and ability to dissolve polar and nonpolar compounds, DMSO has become indispensable in industries ranging from pharmaceuticals to agrochemicals. Over 72% of chemical manufacturers prioritize DMSO for its low toxicity and high permeability, making it a cornerstone in formulations requiring efficient solute delivery.
DMSO’s unique molecular structure enables it to penetrate biological membranes, a trait leveraged in drug development for enhancing API bioavailability. Its dielectric constant of 48.9 facilitates reactions in cryopreservation and polymer synthesis. Additionally, DMSO’s stability under extreme temperatures (-60°C to 150°C) ensures reliability in processes like semiconductor cleaning, where residue-free performance is critical.
Supplier | Purity (%) | Price per Liter ($) | Delivery Time |
---|---|---|---|
Sigma-Aldrich | 99.9 | 220 | 5-7 days |
TCI Chemicals | 99.5 | 195 | 7-10 days |
Merck Group | 99.8 | 240 | 3-5 days |
Cost variations reflect purity grades and logistical efficiency. Bulk procurement (500+ liters) from Merck reduces per-unit costs by 12-15%, while TCI offers mid-tier options for budget-conscious buyers.
Tailored DMSO blends address niche demands, such as ultra-high-purity (≥99.95%) solvents for OLED manufacturing or water-DMSO mixtures for cryopreservation. Customization includes packaging (drums, IBCs), additive integration (stabilizers, antioxidants), and compliance documentation (REACH, USP).
Pharma Case: A European biotech firm reduced API crystallization time by 40% using DMSO as a co-solvent. Electronics Case: A Japanese semiconductor plant achieved 99.7% purity in wafer cleaning by switching to Merck’s DMSO-grade solvent, minimizing microcontamination risks.
Despite its low acute toxicity, DMSO requires PPE (nitrile gloves, goggles) to prevent dermal absorption. Storage in amber glass or HDPE containers under nitrogen atmosphere prevents oxidation. Spill management mandates neutralization with activated carbon, adhering to OSHA guidelines.
Emerging research highlights DMSO’s potential in biodegradable battery electrolytes and mRNA vaccine stabilizers. With the global DMSO market projected to grow at a CAGR of 5.2% until 2030, innovations in green synthesis and closed-loop recycling will drive sustainable adoption.
(organic solvent dmso)
A: DMSO is widely used as a polar aprotic solvent in pharmaceuticals, chemical synthesis, and cell cryopreservation. It effectively dissolves polar and nonpolar compounds, making it versatile for lab and industrial applications. Its permeability-enhancing properties also aid drug delivery systems.
A: DMSO solvent price depends on purity grade, volume purchased, and supplier sourcing. High-purity (e.g., ≥99.9%) pharmaceutical-grade DMSO costs more than industrial-grade versions. Bulk purchases often reduce per-unit pricing significantly.
A: Yes, DMSO can react with strong oxidizing agents or electrophiles, requiring careful compatibility checks. It may also dissolve certain plastics, so glass or PTFE containers are recommended. Always review safety data sheets before use.
A: DMSO is generally safe at low concentrations (typically ≤1%) for cell culture and in vivo studies. Higher concentrations may cause cytotoxicity or alter membrane permeability. Sterile-filtered, reagent-grade DMSO is preferred for biological use.
A: Store DMSO in airtight, light-resistant containers at room temperature (15-25°C). It is hygroscopic and absorbs water, which can affect reactivity, so keep containers sealed. Avoid contact with moisture and oxidizing agents during storage.